As cloud environments grow in complexity, so do the challenges in both cyber defense and incident response (IR). This session delves into notable multi-cloud incidents from 2025, dissecting destructive and intricate cases. We will explore effective cyber defense and detection strategies crucial for mitigating such threats, alongside proven techniques for navigating complex IR scenarios once an incident occurs. Drawing on cross-functional expertise, this presentation will provide actionable insights for security professionals. Attendees will gain a deeper understanding of emerging threats, proactive defense measures, and best practices for robust multi-cloud detection and incident response.